Two novelcoronaviruseshaveemergedto

Two novelcoronaviruseshaveemergedtocauseseverediseaseinhumans.Whilebatsmaybethe
primary reservoirforbothviruses,SARScoronavirus(SARS-CoV)likelycrossedintohumansfromcivets
in China,andMERScoronavirus(MERS-CoV)hasbeentransmittedfromcamelsintheMiddleEast.
UnlikeSARS-CoVthatresolvedwithinayear,continuedintroductionsofMERS-CoVpresentanon-going
public healththreat.Animalmodelsareneededtoevaluatecountermeasuresagainstemergingviruses.
With SARS-CoV,severalanimalspecieswerepermissivetoinfection.Incontrast,mostlaboratory
animals arerefractoryoronlysemi-permissivetoinfectionwithMERS-CoV.Thishost-rangerestriction
is largelydeterminedbysequenceheterogeneityintheMERS-CoVreceptor.Wedescribeanimal
models developedtostudycoronaviruses,withafocusonhost-rangerestrictionatthelevelofthe
viral receptoranddiscussapproachestoconsiderindevelopingamodeltoevaluatecountermeasures
against MERS-CoV.

ผลลัพธ์ (ไทย) 2:

สอง novelcoronaviruseshaveemergedtocauseseverediseaseinhumans.Whilebatsmaybethe
reservoirforbothviruses หลัก SARScoronavirus (โรคซาร์ส COV) likelycrossedintohumansfromcivets
ใน healththreat.Animalmodelsareneededtoevaluatecountermeasuresagainstemergingviruses. ด้วยโรคซาร์ส COV, severalanimalspecieswerepermissivetoinfection.Incontrast, mostlaboratory สัตว์ arerefractoryoronlysemi-permissivetoinfectionwithMERS-CoV.Thishost-rangerestriction เป็น largelydeterminedbysequenceheterogeneityintheMERS-CoVreceptor.Wedescribeanimal รุ่น developedtostudycoronaviruses, withafocusonhost-rangerestrictionatthelevelofthe receptoranddiscussapproachestoconsiderindevelopingamodeltoevaluatecountermeasures ไวรัสกับเมอร์ส-COV

ผลลัพธ์ (ไทย) 3:

สอง novelcoronaviruseshaveemergedtocauseseverediseaseinhumans . whilebatsmaybethe
หลัก reservoirforbothviruses sarscoronavirus ( หากมี ) , likelycrossedintohumansfromcivets
ในประเทศจีน andmerscoronavirus ( mers cov ) hasbeentransmittedfromcamelsinthemiddleeast .
unlikesars covthatresolvedwithinayear continuedintroductionsofmers , covpresentanon ไป
healththreat สาธารณะ .animalmodelsareneededtoevaluatecountermeasuresagainstemergingviruses .
กับโรคซาร์ส มี severalanimalspecieswerepermissivetoinfection . และ mostlaboratory
สัตว์ arerefractoryoronlysemi permissivetoinfectionwithmers ปก thishost rangerestriction
เป็น largelydeterminedbysequenceheterogeneityinthemers covreceptor . wedescribeanimal
developedtostudycoronaviruses รุ่น ,withafocusonhost rangerestrictionatthelevelofthe

กับไวรัส receptoranddiscussapproachestoconsiderindevelopingamodeltoevaluatecountermeasures mers ปก