literature viz. spectrophotometry [10,11], gas chromatography [12],
HPTLC [13], HPLC [14–18]. Recently,HPLC–MS and CE
methods have been reported to characterize the DTZ metabolites
[19–22]. ARP-HPLC method using monolithic silica support for
separation of DTZ and its impurities has been published [23]. Two
validated stability indicating HPLC methods have also been
reported forDTZ in bulk drug [24] and in tablets [25]. These
stability indicating analytical methods are validated for assay of
DTZ, and not for analyzing the drug in the presence of its known
impurities.