this paper niosomal formulations containing resveratrol,alpha-tocopherol and curcumin as single agents and in combi-nation were developed and the effects of their co-encapsulationon the physico-chemical properties of the carriers, their antiox-idant properties and in vitro percutaneous permeation profileswere evaluated. Results showed that the co-encapsulation ofresveratrol/curcumin and alpha-tocopherol/curcumin affected thephysico-chemical properties of niosomes and the entrapment effi-ciencies values, respect to the formulations containing the singleantioxidant.