Withhold therapy prior to each LDL apheresis. Monitor WBC if used in patients w/ collagen vascular disease, immunosuppressant therapy, treatment w/ allopurinol or procainide. Monitor BP, renal function & serum K if high risk of symptomatic hypotension. Aortic & mitral valve stenosis, hypertrophic cardiomyopathy. Renal & hepatic impairment, cardiac ophic cardiomyopathy. Renal & hepatic impairment, cardiac