All horses remained clinical healthy. Clinically significant changes
in haematology, clinical chemistry or coagulation panels were not
detected. Platelet aggregation induced by collagen did not change
at any time points. ANOVAs for ADPtest, ADPtestHS and ASPItest
showed significant changes over time (P < 0.0001). Platelet functions
were significantly inhibited (P < 0.01) 6 h after the
administration of the loading dose. These inhibitions were maintained
until T24 and for 3 subsequent days (Table 2). After cessation
of clopidogrel, platelet function, as measured by ADPtest and
ADPtestHS, remained significantly inhibited (P < 0.01) until T192.
Six days after the last administration of medication (T240), the mean
baseline values were recovered. Platelet function, as measured with
the ASPItest, remained significantly inhibited (P < 0.01; T192 and
T240 P < 0.05) until the final measurement
All horses remained clinical healthy. Clinically significant changesin haematology, clinical chemistry or coagulation panels were notdetected. Platelet aggregation induced by collagen did not changeat any time points. ANOVAs for ADPtest, ADPtestHS and ASPItestshowed significant changes over time (P < 0.0001). Platelet functionswere significantly inhibited (P < 0.01) 6 h after theadministration of the loading dose. These inhibitions were maintaineduntil T24 and for 3 subsequent days (Table 2). After cessationof clopidogrel, platelet function, as measured by ADPtest andADPtestHS, remained significantly inhibited (P < 0.01) until T192.Six days after the last administration of medication (T240), the meanbaseline values were recovered. Platelet function, as measured withthe ASPItest, remained significantly inhibited (P < 0.01; T192 andT240 P < 0.05) until the final measurement
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