risk of developing end-stage kidney disease with a need for renal replacement therapy. Perhaps the greatest challenge is the risk of recurrence of the disease post-transplant, which is 30-50% for the first graft and higher for subsequent one [6]. The nature of the condition and the proportion of familial forms of NS have led to much work on the genetics of NS, with a resultant expansion in the knowledge of genes involved.
This article reviews the pathogenesis, clinical presentation, diagnosis, complications, management and long term outcome of children with steroid sensitive NS.
risk of developing end-stage kidney disease with a need for renal replacement therapy. Perhaps the greatest challenge is the risk of recurrence of the disease post-transplant, which is 30-50% for the first graft and higher for subsequent one [6]. The nature of the condition and the proportion of familial forms of NS have led to much work on the genetics of NS, with a resultant expansion in the knowledge of genes involved.This article reviews the pathogenesis, clinical presentation, diagnosis, complications, management and long term outcome of children with steroid sensitive NS.
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