Friction blisters
The unbroken skin over a blister provides a natural barrier to infection. It's important that the skin remains intact to avoid infection.
As tempting as it may be, try not to pierce a blister with a needle because it could lead to an infection or slow down the healing process. Allow the skin to peel off on its own after the skin beneath has healed.
You may choose to cover small blisters with a plaster. Larger blisters can be covered with a gauze pad or dressing that can be taped in place.
Painful blisters, or those in positions where they are likely to burst, such as on the sole of your foot, can be covered with a soft dressing to cushion and protect them. Change the dressing daily and wash your hands before touching the blister to avoid infection.