However, it is important to note that it is not a general rule that essential oil nanoparticles
show more antimicrobial activity than macro-particles. For instance Terjung et al.,
(2012) reported that essential oil components like carvacrol were more antimicrobially active
in emulsions with particle size 3000 nm rather than in nanoemulsion with particle size 80 nm.
They concluded that the process is dependent on the concentration of the antimicrobial in the
aqueous phase (as we previously mentioned), which is controlled by its preferential location
relative to the oil/water interface or its solubilization in the excess surfactant micelles or
both.