Abstract
One of the most important drug-related problems in patients with chronic kidney disease
(CKD) is medication dosing errors. Many medications and their metabolites are eliminated
through the kidney. Thus, adequate renal function is important to avoid toxicity. Patients with
renal impairment often have alterations in their pharmacokinetic and pharmacodynamic parameters.
The clearance of drugs eliminated primarily by renal fi ltration is decreased by renal
disease. Therefore, special consideration should be taken when these drugs are prescribed to
patients with impaired renal function. Despite the importance of dosage adjustment in patients
with CKD, such adjustments are sometimes ignored. Physicians and pharmacists can work
together to accomplish safe drug prescribing. This task can be complex and require a stepwise
approach to ensure effectiveness, minimise further damage and prevent drug nephrotoxicity