F4 formulation of SLNs has showed maximum entrapment (82.1%) due to high affinity of drug with lipid matrix
F4 showed significantly less drug release over other formulations which clearly indicated that they can provide satisfied result for acne treatment over prolonged period of time.
SLNs dispersions as carriers for delivery of Neem oil was exploited. Solid lipid Nanoparticles were prepared by the w/o/w type double emulsification method by using bio-acceptable lipids such Cholesterol and Lecithin and tween 80 as emulsifier
Drug loaded SLNs showed average diameters in the narrow colloidal size range, a good loading capacity and drug release.
Strongly support the potential application of SLNs as drug delivery system in acne treatment