Background—Mortality among long-term hemodialysis patients is high, mostly attributed to
cardiovascular events, and may be related to chronic inflammation. We hypothesized that the anti-
inflammatory benefits of higher dietary omega-3, compared to omega-6, poly-unsaturated fatty
acids may modulate the inflammatory processes and reduce death risk.
Study design—Prospective cohort study using linear and Cox proportional regressions.
Setting and Participants—145 hemodialysis patients from 8 DaVita dialysis clinics in
Southern California during 2001-2007
Predictors—Intake of dietary omega-3 and ratio of omega-6 to omega-3 using 3-day food record
supplemented by dietary interview.
Outcomes—One-year change in serum C-reactive protein (CRP) and 6-year survival.
Results—Patients were 53±14 years old (mean±SD) and included 43% women and 42%
African-Americans. Median (25th-75 percentile) of dietary omega-3 intake, ratio of omega-6 to
omega-3 intake, baseline serum CRP, and change in CRP over one year were 1.1(0.8-1.6) g/day,
9.3(7.6-11.3), 3.1(0.8-6.8) mg/L, and +0.2(−0.4 to +0.8) mg/L, respectively. In regression models
adjusted for case-mix, dietary calorie and fat intake, body mass index and history of hypertension
Background—Mortality among long-term hemodialysis patients is high, mostly attributed to
cardiovascular events, and may be related to chronic inflammation. We hypothesized that the anti-
inflammatory benefits of higher dietary omega-3, compared to omega-6, poly-unsaturated fatty
acids may modulate the inflammatory processes and reduce death risk.
Study design—Prospective cohort study using linear and Cox proportional regressions.
Setting and Participants—145 hemodialysis patients from 8 DaVita dialysis clinics in
Southern California during 2001-2007
Predictors—Intake of dietary omega-3 and ratio of omega-6 to omega-3 using 3-day food record
supplemented by dietary interview.
Outcomes—One-year change in serum C-reactive protein (CRP) and 6-year survival.
Results—Patients were 53±14 years old (mean±SD) and included 43% women and 42%
African-Americans. Median (25th-75 percentile) of dietary omega-3 intake, ratio of omega-6 to
omega-3 intake, baseline serum CRP, and change in CRP over one year were 1.1(0.8-1.6) g/day,
9.3(7.6-11.3), 3.1(0.8-6.8) mg/L, and +0.2(−0.4 to +0.8) mg/L, respectively. In regression models
adjusted for case-mix, dietary calorie and fat intake, body mass index and history of hypertension
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