TNF-a activates many signaling cascades upon binding with its
specific receptor on cell surface. Nuclear-Factor kappa B (NF-kB) is
one of the prominent ones. NF-kB activation is facilitated by conditions
associated with increased intracellular oxidative stress.
Reactive oxygen species (ROS) generated during inflammation not
only helps to kill pathogens but also acts as important signaling
molecules by changing the intracellular redox balance