Aims: To assess the effect of physical activity in patients with type 2 diabetes mellitus on
prevention of diabetes with chronic kidney disease.
Methods: This is a cohort study on stratified selected subjects in Taiwan from 2004/01/01 to
2005/12/31. Demographic data, lifestyle factors and clinical characteristics were analyzed for
an association with the occurrence of chronic kidney disease. Applicable analysis weights,
Stata 11.0, were applied to adjust the design variables for clustering and stratification.
Results: During the two year study period, the univariate Cox proportional hazards model
showed significant associations of age, physical activity, and the Charlson comorbidity index
(CCI) with chronic kidney disease. Physical activity had a beneficial effect in diabetic subjects
with chronic kidney disease (HR: 0.31, p < 0.01). Older age and a CCI greater than 2 were both
harmful in diabetic subjects with chronic kidney disease (1.06 and 3.44, respectively). The
results of a multivariate Cox proportional hazards evaluation model were similar to those
of a univariate evaluation model, except that CCI was not significantly different. Moreover,
medications for hypertension of diabetic subjects created an increased risk of chronic kidney