Lastly, among 60 727 patients with more than one eligible biopsy record (biopsy sample taken within two years of a gastric cancer diagnosis were disregarded) in Correa’s cascade subcohort, we performed supplementary estimations of standardised incidence ratios for each baseline histology group after stratification according to the direction of any change in classification prompted by the histological re-evaluations. Thus, within each baseline histology group, those with more advanced lesions in re-endoscopies were grouped into the “progression” stratum; correspondingly, those with less advanced lesions were grouped into the “regression” stratum, and all others into the “no change” stratum.