Ethnopharmacological relevance:Arecacatechu Linn. (Arecaceae)nutisapopularfolkremedyforthe
treatment ofmigraineinKeralaandTamilNadustatesofIndia.
Aim ofthestudy: This studywasdesignedtoinvestigatetheeffectofhydroalcoholicextractof A.catechu
L. nut(ANE)treatmentonmigrainepaininratmodelstostrengthenitsuseasananti-migrainetherapy.
Materials andmethods: Bradykinin(0.1 μmol/kg) injectionintoleftfemoralveinofratproducedPPE
which wasmeasuredwithluminescencespectrometer.Vocalizationswereproducedinratswith10 μg of
bradykinin infusionintocommoncarotidartery.Phonogramwasrecordedbefore,duringandfor5min
afterbradykinininjectionandsumatriptanwasusedasastandardanti-migrainedrug.Inbothmodels,
the ANEwasorallyadministeredatdosesof250and500mg/kg,60minbeforebradykinininfusion.
Results: The PPEwasreducedinbothANEtreatedgroupsofrats.Thepercent fluorescein was
significantly increasedinpositivecontrolgroup(97.0071.7%; po0.0001)comparedtonegativecontrol
(63.8771.2%).WithANEtreatments(250and500mg/kg)PPEwassignificantly decreasedto
88.8871.4%(po0.01)and83.5570.1%(po0.0001)comparedtopositivecontrolgroup,respectively.
On theotherhandinthemodelofvocalization,with250and500mg/kgANEtreatment,vocalizationwas
significantly reducedto33.33%and16.66%,respectively,comparedtosalinetreatedrats.Thereductionin
vocalization iscomparabletothereferencedrugsumatriptan.
Conclusion: The findings providethestrongevidenceforanti-migrainepotentialofANEinratmodelsof
migraine. Insummary,therapeuticinterventionwithANEtreatmentcouldbeapromisingstrategyfor
preventionofmigraine.
เกี่ยว Ethnopharmacological: Arecacatechu Linn Nutisapopularfolkremedyforthe (Arecaceae)รักษา ofmigraineinKeralaandTamilNadustatesofIndiaจุดมุ่งหมาย ofthestudy: นี้ studywasdesignedtoinvestigatetheeffectofhydroalcoholicextractof A.catechuL. อ่อนนุช (ANE) treatmentonmigrainepaininratmodelstostrengthenitsuseasananti-migrainetherapyAndmethods วัสดุ: injectionintoleftfemoralveinofratproducedPPE Bradykinin (0.1 ไมโครโมล/กิโลกรัม)ที่ wasmeasuredwithluminescencespectrometer Μ Vocalizationswereproducedinratswith10 ของbradykinin infusionintocommoncarotidartery Phonogramwasrecordedbefore, duringandfor5minafterbradykinininjectionandsumatriptanwasusedasastandardanti-migrainedrug InbothmodelsANEwasorallyadministeredatdosesof250and500mg กิโลกรัม 60minbeforebradykinininfusionผลลัพธ์: PPEwasreducedinbothANEtreatedgroupsofrats.Thepercent fluorescein ถูกcomparedtonegativecontrol increasedinpositivecontrolgroup (97.0071.7%; po0.0001) อย่างมีนัยสำคัญ(63.8771.2%) WithANEtreatments(250and500mg/kg) PPEwassignificantly decreasedto88.8871.4%(po0.01)and83.5570.1%(po0.0001)comparedtopositivecontrolgroup,respectivelyTheotherhandinthemodelofvocalization, with250and500mg/kgANEtreatment, vocalizationwasreducedto33.33%and16.66%,respectively,comparedtosalinetreatedrats อย่างมีนัยสำคัญ Thereductioninvocalization iscomparabletothereferencedrugsumatriptanสรุป: การค้นพบ providethestrongevidenceforanti-migrainepotentialofANEinratmodelsofไมเกรน Insummary, therapeuticinterventionwithANEtreatmentcouldbeapromisingstrategyforpreventionofmigraine
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ความสัมพันธ์กัน Ethnopharmacological: Arecacatechu ลินน์ (ปาล์ม) nutisapopularfolkremedyforthe
ofmigraineinKeralaandTamilNadustatesofIndia รักษา.
เล็ง ofthestudy: studywasdesignedtoinvestigatetheeffectofhydroalcoholicextractof นี้ A.catechu
ลิตร น๊อต (ANE) treatmentonmigrainepaininratmodelstostrengthenitsuseasananti-migrainetherapy.
andmethods วัสดุ: Bradykinin (0.1 ไมโครโมล / กิโลกรัม) injectionintoleftfemoralveinofratproducedPPE
ซึ่ง wasmeasuredwithluminescencespectrometer.Vocalizationswereproducedinratswith10 ไมโครกรัมของ
bradykinin infusionintocommoncarotidartery.Phonogramwasrecordedbefore, duringandfor5min
afterbradykinininjectionandsumatriptanwasusedasastandardanti-migrainedrug.Inbothmodels,
ANEwasorallyadministeredatdosesof250and500mg / กก 60minbeforebradykinininfusion.
ผลการ PPEwasreducedinbothANEtreatedgroupsofrats.Thepercent fluorescein เป็น
อย่างมีนัยสำคัญ increasedinpositivecontrolgroup (97.0071.7%; po0.0001) comparedtonegativecontrol
. (63.8771.2%) WithANEtreatments (250and500mg / kg) PPEwassignificantly decreasedto
88.8871.4% (po0.01) and83.5570.1% (po0.0001) comparedtopositivecontrolgroup, . ตามลำดับ
ใน theotherhandinthemodelofvocalization, with250and500mg / kgANEtreatment, vocalizationwas
อย่างมีนัยสำคัญ reducedto33.33% and16.66% ตามลำดับ comparedtosalinetreatedrats.Thereductionin
โฆษะ iscomparabletothereferencedrugsumatriptan.
สรุป: ผลการวิจัย providethestrongevidenceforanti-migrainepotentialofANEinratmodelsof
ไมเกรน Insummary, therapeuticinterventionwithANEtreatmentcouldbeapromisingstrategyfor
preventionofmigraine
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