Abstract
Background and objectives: This study aimed to assess the dose-dependent effect of antioxidants in
protection against cardiovascular changes induced by exposure to cigarette smoke.
Design and setting: This was an experimental study, conducted at King Fahd Medical Research
Center, King Abdulaziz University.
Materials and methods: This study was carried out on 57 male albino rats divided into nine groups.
Rats of experimental groups were exposed to cigarette smoke from a total of 100 cigarettes per week
for four weeks in a specially designed chamber. The antioxidants used (vitamin C, E, and B-carotene)
were administrated at low (9, 7.2, and 0.27 mg/day) and high doses (18, 14.4, and 0.54 mg/day),
respectively, through gastric feeding tubes. The lipid profile was estimated, and the carotids and heart
were removed, weighed, and then processed, and the carotid intima-media thickness was measured.
Statistical analysis was performed using the Statistical Package for Social Sciences
AbstractBackground and objectives: This study aimed to assess the dose-dependent effect of antioxidants inprotection against cardiovascular changes induced by exposure to cigarette smoke.Design and setting: This was an experimental study, conducted at King Fahd Medical ResearchCenter, King Abdulaziz University.Materials and methods: This study was carried out on 57 male albino rats divided into nine groups.Rats of experimental groups were exposed to cigarette smoke from a total of 100 cigarettes per weekfor four weeks in a specially designed chamber. The antioxidants used (vitamin C, E, and B-carotene)were administrated at low (9, 7.2, and 0.27 mg/day) and high doses (18, 14.4, and 0.54 mg/day),respectively, through gastric feeding tubes. The lipid profile was estimated, and the carotids and heartwere removed, weighed, and then processed, and the carotid intima-media thickness was measured.Statistical analysis was performed using the Statistical Package for Social Sciences
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