8 In addition to the opportunity presented by large
numbers of potentially treatment-naı¨ve participants
that could be accessed in international sites, the
opportunity to significantly increase accrual and
conduct large-scale multisite studies of interventions
is attractive to investigators.89 As the global clinical
research enterprise grows, questions about the role of
staff to support research, including the roles of clinical
research nurses, become important. The Association of
Clinical Research Professionals has a broad international
membership and has featured articles in its
professional publications about the developing clinical
research infrastructure in India,90 Austria and
Hungary,91 and South Africa.92