GC-MS-MS technique is used for detecting drugs whose mass spectra is unavailable. In this technique the detection of drugs can be done by following mass frontier. Simple laws of organic chemistry and predictions can be made theoretically by choosing electron impact or chemical ionization. The mass frontier is similar to mass spectra interpreter at tips of finger which helps in the development of MS-MS method, target compounds can be isolated from the matrix and falls positives from the analysis can be eliminated. Hence this is an effective