Dolion This is probably the most remarkable example of how far science is able to go with modern DNA and cross fertilizationtechniques; the dolion is a uoss between a lion and a dog. In order to produce this incredible rare animal. In 2002, the first genetically modified dolion was made in a laboratory. after that the other two were made down the line. , individual strands of DNA from each creature must be combined and re-inserted in to a host egg. This is similar to the liger (lion/tiger crossbreed) with the exception that the liger is able to be produced without prior manipulation of theDNA of either breed of animal. The liger is a hybrid cross between a male lion (Panthera leo) and a tigress (Panthera tigris).