In the present study, few derivatives of acetanilide (IIV) are synthesized by conventional method as well as green synthesis method. The synthesized compounds are characterized by their physical constants and FTIR. Both the method gives the desired products, but by applying the green synthesis method, we can able to avoid the use of acetic anhydride and formation of by products. Moreover, the atom economy was obtained in the range of 72% to 82% which indicates the complete use of chemicals. Thus, concept of green chemistry can be applied to various synthetic methods. This may leads to generation of eco friendly synthetic chemistry.