Some adults receiving oseltamivir (tamiflu) have also reported nausea and vomiting (Ryan, Ticehurst, & Dempsey, 1995). Furthermore, high-level drug resistance is associated with both inhibitors. In 2009, oseltamivir-resistant H1N1 viruses arose spontaneously and spread globally. This resistance was conferred by a single amino acid change in the viral neuraminidase (H274Y) (Hurt, Holien, Parker, & Barr, 2009). Therefore, continuous research for new antiviral compounds from natural products is needed to develop new therapeutic agents in the battle against the influenza viruses (De Clercq, 2006).
Some adults receiving oseltamivir (tamiflu) have also reported nausea and vomiting (Ryan, Ticehurst, & Dempsey, 1995). Furthermore, high-level drug resistance is associated with both inhibitors. In 2009, oseltamivir-resistant H1N1 viruses arose spontaneously and spread globally. This resistance was conferred by a single amino acid change in the viral neuraminidase (H274Y) (Hurt, Holien, Parker, & Barr, 2009). Therefore, continuous research for new antiviral compounds from natural products is needed to develop new therapeutic agents in the battle against the influenza viruses (De Clercq, 2006).
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