Colorectal cancer (CRC) is one of the most prevalent types of
cancer worldwide and a common cause of morbidity and
mortality in humans (1). According to the reports of the
Department of Health, Taiwan (ROC) in 2009, colorectal cancer
is the third leading cause of cancer-related death in Taiwan,
accounting for 11.4% of all cancer deaths. In clinical practice,
surgery, radiotherapy and chemotherapy are main strategies for
treating colon cancer patients. Significant improvements in
patient survival rates have been achieved in recent years due to
successful treatment (2). However, most patients still die of their
disease. Approximately 20% of patients have distant metastatic
disease at the time of presentation and are rarely cured (3). The
median overall survival duration for patients with metastatic
disease is currently about 20 months (4). Chemotherapy
resistance in cancer is one of the most serious obstacles.
Therefore, in this study, we focus on identifying a new agent to
treat colorectal cancer.