Time is a critical factor in a potential overdose situation. Prompt response can have a significant impact on patient outcome (Goldfrank, 2006). In addition to notifying all personnel listed on the notification algorithm, the oncology treatment team may contact the state poison control center to obtain additional information. Initial general interventions should include establishing IV access and beginning hydration and forced diuresis, if not contraindicated. After consulting current pharmacology and toxicology references, the oncology team should create a list of possible side effects and initiate specific prophylaxis measures based on involved systems