Macrolides (MLs) (e.g., lincomycin, azithromycin, tilmicosin, erythromycin and roxithromycin) are synthetic antibiotics used in animal husbandry, aquaculture, and humanmedicine. The presence of even a trace level of macrolides in food products would lead to side effects (e.g., allergic reactions, the appearance of resistant bacteria, and even cross-resistance to other antibiotics).Wu et al. used 2-D graphene as the sorbent to extract and to enrich MLs from fish samples by SPE. They found that graphene was a superior SPE sorbent fordetermination and confirmation of MLs and polycyclic aromatic hydrocarbons residue in food and water samples