trafficked with OMVs into endo-lysosomal compartments.
Upon endosome acidification and subsequent decrease in
pH, EHEC-Hly is separated from OMVs, escapes from the
lysosome, and targets mitochondria. Subsequent activation
of caspase-9 and caspase-3 leads to apoptotic cell death.
The OMVs-mediated intracellular delivery represents a
newly recognized mechanism for a bacterial toxin to enter
host cell in order to target mitochondria