gastric acid secretion [85]. Members of this group include omeprazole, ole, pantoprazole, rabeprazole, and esomeprazole. The standard doses of each drug type can exert a similar acid inhibitory effect. Omeprazole is the agent with the longest documented safety record, whereas the newest agents, rabeprazole and pantoprazole may interact than the other two with cytochome P450 metabolism [86]. Several trials have shown the superiority of PPIs over H2RAs in the treatment of reflux esophagitis. Klinkenberg Knol et al. [87] have documented effective long-term control of GERD with PPIs, showing that long-term therapy with omeprazole in regular doses (20 to 60 mgld) maintains healing of esophagitis for up to 11 years. PPIs in standard doses control symptoms in more than 80% of cases and heal esophagitis in almost 90% of cases within a period