None of the 275 patients who continued warfarin experienced serious (or major)
bleeding. The mean INR across studies of patients who continued warfarin was between 1.8 and 3.4 (Table 1),
suggesting that patients were therapeutically anticoagulated at the time of the dental procedure; therefore, the observed low rates of bleeding are not likely attributable to a systematically lower intensity of anticoagulation. Further, the follow-up period after dental procedures was at least 6 days for all studies, the time frame during which most procedure-related bleeding events occur,25 thus reducing the likelihood that bleeding events were missed.