On skin level, the IgE-mediated immune response is dependent
on both chemical and neurogenic mediators.11,12
After intracutaneous injection, allergens cross-link preformed
IgE bound to the high-affi nity receptor FcERI mast
cells and a complex signal transduction cascade is activated.
This eventually culminates in mast-cell degranulation beginning
in seconds, with release of a variety of preformed inflammatory
mediators.