Hemolytic Uremic Syndrome
First described in 1955, now most common cause of kidney failure in childhood.
5% - 10% of EHEC cases will develop HUS,usually within 2-14 days after diarrhea.
90% of HUS is caused by strain E. coli O157:H7.
Caused when E. coli enters the circulation through the inflamed intestinal wall and releases SLT.
SLT attach to receptors on the endothelial cells.
Kidney, pancreas and brain most susceptible.
Characteristic symptoms include hemolytic anemia, thrombocytopenia, and renal failure.