Natural rubber latex (NRL) is often used to prepare the blended films by solution-casting technique. Its film presents
interesting physical properties in elasticity and adhesiveness. From the good physical properties of NRL, it can be
used to prepare transdermal patches which gain popularity due to several advantages such as convenient application,
avoid first-pass metabolism, possibly to attain sustained and constant drug levels. However, the skin serves an
excellent barrier against drug permeation due to the rigid lamellar structure of the stratum corneum lipids. Enhancers
can improve the partition of drug into the stratum corneum by increasing the thermodynamic activity of the drug in
transdermal formulations