The three dimensional homology model of the COXIIa and COXIIb
complexes is shown in Fig. 2 C, left. Electrostatic potential surfaces
were calculated in order to analyze and compare the charge distribution
of the produced 3D model to its template structure (Fig. 3). The two
complexes exhibited almost identical electrostatic surfaces, sharing
common features that were not disturbed by the addition of the two
extra alpha helic on the homology model. There is a hydrophobic, uncharged
region in the mid section of the two complexes (depicted by
white boxes) that is vital to its function that has been conserved, despite
the addition of the insert structures. This observation verified the validity
of the model, which was found to share similar electrostatic surface
of almost identical intensity, to its X-ray determined template structure.