The intestinal type is more common and mainly
affects older people. It may be related to H. pylori
infection and diet. In contrast, the diffuse type is more
common in younger patients, can be hereditary and
is characterised by signet ring cells (Newman and
Mulholland 2006). Aetiopathology of the diffuse type is
less well understood and carries a worse prognosis (Shah
and Kelsen 2010). Newman and Mulholland (2006)
state that E-cadherin gene mutations (HDGC) are found
exclusively in cancer of the isolated cell or diffuse type.