in order to initiate an ecological shift in the cariogenic biofilm. This
objective would be better attained with a narrow spectrum antimicrobial
agent, active against Streptococcus species, presenting a low
allergenic potential and poor absorption through the gastrointestinal
tract. The search for a substance with such specific and favorable
properties led to in vivo testing of vancomycin, and a reduction in
plaque MS was observed