If CNS depression is severe consider the use of the benzodiazepine antagonist Anexate® (active ingredient: flumazeni). This should only be administered under closely monitored conditions. It has a short half-life (about an hour); therefore patients administered fumazeni will require monitoring after its effects have worn off. Flumazenil s to be used with extreme caution in the presence of drugs that reduce seizure threshold (e.g. tricyclic antidepressants)