Endophytic organisms associated with plants are varied and complex. Endophytic microbes occupy a relatively privileged niche within plant and usually contribute to plant health. Some groups of endophytic microorganisms have been believed to be mutualists that protect plants against biotic stresses. Co-evolution may exist between endophytes and their host in resist to environmental stresses. During the last two decades endophytes have been targeted as valuable sources of new bioactive compounds (Tadych, & White, 2009)[15].