A front desk office assistant has a variety of duties. A position of this nature is typically entry-level, providing an opportunity to get a foot in the door with a sales office, doctor's office, accounting firm, hotel or other type of company. The person holding this position will learn a lot about the company's inner workings and manage certain areas of the operation. To obtain a front desk office assistant position, you will likely need a high school diploma or equivalent and previous experience in a similar role.