The present work is focused on plasticizing PLA with three different epoxidized palm oil (EPO) via melt blending technique. EPO is an epoxide derivative of glycerol ester mixture with various saturated and unsaturated fatty acids. In addition, EPO is a renewable, biodegradable, environmentally friendly and cheap raw material [10]. Thus, the aim of this study is to obtain films with enhanced mechanical and thermal properties that are able to be applied in packaging formulations.