Terminalia species (Combretaceae), widely applied in tropical and subtropical ethnomedicine for the treatment of a diverse range of ailments have been reported not only to be tannin-rich, but also to owe most of their biological activities and therapeutic applications to their tannin contents [13-17]. Therefore, as part of our continuing efforts into finding suitable leads for useful drugs from plants, we hypothesised the possible discovery of HCV protease interactive and, hence possible inhibitor tannins from the exploration of tannin chemical space of the genus Terminalia. The current study was focused on isolating tannins from methanolic extracts of the ethnomedicinally used fruit flesh and kernel parts Terminalia chebula, and subjecting the isolates to HCV NS3/4A protease nhibition investigations, with a view to providing leads for the