It is not recommended for
use in herds where cows are thin, or where a majority of the cows are less than 60 dpp at program initiation,
since there is a higher probability that these females will be anestrus.An additional disadvantage of the CO-Synch
program is that a proportion (~10%) of cows will exhibit estrus and ovulate between days -1 and 1 and
these animals will not conceive if strictly timed-AI is
used. Producers who have the labor and facilities to
accommodate estrus detection between days -2 and 1
can AI these cows that exhibit premature estrus.