Synthetic biology has emerged as a new discipline ingenetic engineering for the design and construction ofnovel biological systems [1]. All information about pro-tein expression is written on the DNA sequence integratedin a biological system that is further modulated by mech-anisms acting beyond the central dogma. The simplestprotein expression cassette, for example, is composed ofa regulatory sequence and a protein coding sequence, eachof which is encoded by DNA segments made of the four