Metabolic changes of type 1 DM (cont.) Metabolic & Clinical Abnormalities in DKA Carbohydrates Metabolism Carbohydrates Metabolism In Sk. Ms. & Adipose In Liver Glucose Uptake Glycogenlysis Glucose Uptake Glycogenlysis Gluconeogenesis Gluconeogenesis Lipids Metabolism Lipids Metabolism Lipolysis Lipolysis in Adipose Tissue in Adipose Tissue Fatty Acids in liver in liver ketone Bodies (KETOGENESIS) (KETOGENESIS) Protein Metabolism Protein Metabolism Proteolysis Uptake of AA by liver Uptake of AA by liver Gluconeogenesis Gluconeogenesis Hyperglycemia Low Insulin Glycosuria Osmotic diuresis With Loss of water & Na+ & Hypovolemia Ketonemia Polyuria,&Dehydration AcetoneSmelt on Breath MetabolicAcidosis IncreasedRespiration Low GFR Low Renal H+ Excretion Excretion Prerenal Uremia PlasmaOsmolality Thirst Coma Nausea&Vomiting L ow BloodBicarbonate Low pCO2 Ketonuria