Jones et al. [28] reported the experimental infection of groups of four captive-bred, juvenile Egyptian fruit bats inoculated s.c. with each of the five known ebolaviruses. Irrespective of the virus used, no bat became viremic, there was no evidence for viral shedding, and tissue distribution of viral RNA was limited in all but SUDV-inoculated bats. In a follow-up experiment [28] involving 15 bats inoculated s.c. with SUDV, viral RNA was detected in 8 out of 10 different tissues, but in the absence of detectable viremia or viral shedding. The only tissues in which SUDV levels were high enough to suggest possible viral replication were the inoculation site, at Days 3 and 6 p.i., and the spleen in one bat, on Day3 p.i. However, of the 15 bats, viral RNA was detected only in one tissue in eight individuals (skin or axillary lymph node), and in one bat in two tissues (skin and liver). These results seem to indicate notable differences in individual response to s.c. inoculation with SUDV. In contrast, s.c inoculation of R. aegyptiacus with MARV consistently results in systemic infection, including relatively long viremia, viral replication in multiple tissues, and detection of viral RNA in oral and rectal swabs