With the increased public interest in complementary and alternative therapies as well as novel therapies, the clinician is faced with another issue. Because of the desire to avoid medication during childbearing, patients often express interest in non-standard therapies. How much evidence of efficacy must be present to offset concerns about medication therapy? Is the patient (and perhaps physician) trading efficacy of the treatment for the perception of increased safety? If the patient refuses all standard therapies, how should the health professional respond? We briefly review therapies that have been of particular interest to our patients and research team.