Results and Discussion
Following a single IV injection of 10 mg kg-1 BW in healthy
goldfishes, norfloxacin could be detected therapeutically for 24 hours.
The serum concentration – time curve of norfloxacin following IV
injection showed that the drug obeyed a two compartments open
model. The disposition kinetics of norfloxacin following a single IV
and PO administration were recorded in (Tables 1 and 2) and shown
in (Figure 1). Oral administration of 10 mg kg-1 BW every 24 hours
for 5 doses in healthy and Aeromonas hydrophilia infected goldfishes,
revealed a lower significant serum norfloxacin concentration at alltime sampling in Aeromonas hydrophilia infected goldfishes than
in healthy ones (Figure 2). The pharmacokinetic parameters of
norfloxacin after repeated PO administration in healthy goldfishes
were compared to those in Aeromonas hydrophilia infected ones as
shown in (Table 3)