This review also demonstrates that the amount of data regarding the speed of onset of action of AAPs in pediatric psychiatry leaves much to be desired, and future study designs that feature head-to-head comparisons would be extremely valuable. With regard to weight gain, lack of data is not an issue. Since the meta-analysis by Allison et al first highlighted the topic,39 and right through to the present, an abundance of data has been generated concerning use of AAPs and weight gain in both adult and pediatric psychiatry. Unfortunately, ziprasidone, an atypical antipsychotic drug that causes the least weight gain, also appears to be ineffective in EOS.5 Among the effective treatments for EOS, aripiprazole appears to cause the least weight gain