In addition to the neurodegenerative pathways associated with the toxicity of Aβ and P-tau, the involvement of caspases in AD and its apoptic cascade is a major accelerator of cell death (Cavallucci and D’Amelio, 2011). Apoptosis is a programmed cell death pathway characterized by distinct morphological features and biochemical mechanisms enhanced by the slow accumulation of the Aβ peptide within plaques of the brain of patients with AD. Inappropriate apoptosis is associated with neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer (Elmore, 2007).