Hyperemesis gravidarum is defined as intractable
excessive vomiting during pregnancy with onset before the
13th gestational week, usually the woman is unable to
tolerate orally and requires intravenous hydration1
. It is
likely to be associated with hyperthyroidism secondary to
the high hCG level. Various studies showed 0.3 – 1%
prevalence of HG in pregnancy, with a mean onset during
the 3rd gestational week, peaks in 11th–13th gestational
week2
, and subsides after 14th-18th gestational week3
.
Hyperemesis gravidarum is possibly associated with signs of
disturbed nutritional status (alterations in electrolyte balance,
more than 5% weight loss, ketosis, acetonuria), neurological
disturbances, retinal hemorrhage, liver and renal damage2
.
On the other hand, the most common thyroid disease in
all pregnancies is Graves’ disease (85 – 90%), while the
secondly most common is gestational transient
hyperthyroidism, which its incidence is 1–2% in all
pregnancies3,4. Gestational transient hyperthyroidism is
defined as firstly diagnosed hyperthyroidism in early
pregnancy, which resolves spontaneously by the early
second trimester of pregnancy, without evidence of
autoimmune thyroid disease and physical findings
associated with Graves’ disease4
. Gestational transient
hyperthyroidism occurs up to two-thirds of women with
hyperemesis gravidarum1
.