In the previous study for 2 years (1998-2000) with clinical analysis and examination of blood and synovial fluid of osteoarthritis patients, the researcher found that the combination of 15 mg curcuminoid from Curcuam domestiva Val. rhizome extract and 100 mg of essential oil from Curcuam xanthorriza Roxb.was taken 2 times daily for 2 weeks time was comparable to the anti-inflammatory drug piroxicam for the treatment of patients with knee OA by lowering the level of malondialdehyde (MDA) in the blood and synovial fluid and improving the clinical symptoms of the patients.24