. For the method validation of quantification, spiking experiments were
carried out to determine the linearity, recovery, and method detection limit (MDL) using three deuterated
internal standards. The average recovery was 79% within 20% relative standard deviation (RSD) at
the concentration of 50 ng/g. MDLs ranged from 0.46 ng/g to 36.54 ng/g, which was satisfactory for the
directive limit of 50 ng/g proposed by the European Commission (EC). As a result, it was concluded that
the method could be provided for the accurate mass screening, confirmation, and quantification of
n-nitrosamines when applied to cosmetic inspection.
&