cervical cancer is the second most common cancer in women worldwide, and it is the principal cancer of women the possible outcome of genital infection with high risk human papillomavirus (HPV) and is preceded by a phase of persistent HPV infection during which the host immune system fails to eliminate the virus. T-cell response in cervical cancer patients is either absent or severely
as indicated by intact responses against recall antigens. It is highly conceivable that proper CD4 T-cell help is important for launching an effective immune attack against HPV because infection of cervical epithelia by this virus is, at least initially, not accompanied by gross disturbance of this tissue stimuli. Molecular epidemiologic evidence clearly indicates that certain types of human papillomavirus (HPV) are the principal cause of invasive cervical cancer and cervical intraepithelial neoplasia. More than 80 HPV types and about 40 types can infect the genital tract